Article
Screening for ovarian cancer by transvaginal ultrasound and serum CA125 measurement in women with a familial predisposition: a prospective cohort study.
Gynecologic oncology - 1 Dec 2006
Bosse Kristin, Rhiem Kerstin, Wappenschmidt Barbara, Hellmich Martin, Madeja Martin, Ortmann Monika, Mallmann Peter, Schmutzler Rita
Abstract excerpt
OBJECTIVE: This study evaluates the accuracy of transvaginal ultrasound (TVUS) in combination with CA125 to detect ovarian cancer in women at hereditary risk for ovarian cancer. METHODS: A semi-annual surveillance protocol comprising CA125 measurement and TVUS was offered to 676 women including 85 BRCA mutation carriers. Surgical intervention was performed if TVUS revealed a suspicious cyst or if elevated CA125...
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