Article
GSTM1 [corrected] deletion modifies the levels of polycyclic aromatic hydrocarbon-DNA adducts in human sperm.
Mutation research - 3 Oct 2005
Paracchini Valentina, Chang Seong-Sil, Santella Regina M, Garte Seymour, Pedotti Paola, Taioli Emanuela
Abstract excerpt
DNA adducts measured in tissues are promising markers for identifying damage in organs that could be a target for carcinogens. Polymorphisms in genes involved in polycyclic aromatic hydrocarbons (PAHs) metabolism have been shown to modify the levels of PAH-DNA adducts in target tissues. In order to study the role of metabolic gene polymorphisms on DNA-adduct formation in sperm, we determined the GSTM1 genotype in...
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