Article
Real-time PCR assay of individual human immunodeficiency virus type 1 variants in coinfected human lymphoid tissues.
Journal of clinical microbiology - 1 May 2003
Ito Yoshinori, Grivel Jean-Charles, Margolis Leonid
Abstract excerpt
In the course of infection, human immunodeficiency virus type 1 (HIV-1) mutates, diverging into a "swarm" of viral quasispecies, and the predominance of CCR5- or CXCR4-utilizing quasispecies is strongly associated with the pattern of disease progression. Quantification of CCR5- and CXCR4-utilizing viruses in viral swarms is important in the investigation of the mechanisms of this phenomenon. Here, we report on a...
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