In vitro mineralization of osteoblastic cells derived from human bone.

doi:10.1016/0169-6009(90)90109-s

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Article

In vitro mineralization of osteoblastic cells derived from human bone.

Bone and mineral - 1 Mar 1990

Gotoh Y, Hiraiwa K, Nagayama M

Abstract excerpt

Osteoblastic cells were isolated from human maxilla by embedding the bone pieces in collagen gel. The isolated cells could be maintained in monolayer culture up to 50 population doubling levels (PDLs). Both parathyroid hormone (PTH) and prostaglandin E2 (PGE2) increased intracellular cyclic AMP level of the cells. The cells also showed high level of alkaline phosphatase (ALPase) activity and formed mineralized...

Topics

Alkaline Phosphatase
Bone and Bones
Calcification, Physiologic
Calcium
Cell Division
Cell Separation
Cells, Cultured
Child
Collagen
Cyclic AMP
Dinoprostone
Gels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Microscopy, Electron

Osteoblasts

Parathyroid Hormone

Phenotype

Source

Open in PubMed

Identifiers

PMID: 2157512
DOI: 10.1016/0169-6009(90)90109-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157512-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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