Article
14-3-3eta is a novel regulator of parkin ubiquitin ligase.
The EMBO journal - 11 Jan 2006
Sato Shigeto, Chiba Tomoki, Sakata Eri, Kato Koichi, Mizuno Yoshikuni, Hattori Nobutaka, Tanaka Keiji
Abstract excerpt
Mutation of the parkin gene, which encodes an E3 ubiquitin-protein ligase, is the major cause of autosomal recessive juvenile parkinsonism (ARJP). Although various substrates for parkin have been identified, the mechanisms that regulate the ubiquitin ligase activity of parkin are poorly understood. Here we report that 14-3-3eta, a chaperone-like protein present abundantly in neurons, could bind to parkin and...
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