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Article

Mechanism of arginine regulation of acetylglutamate synthase, the first enzyme of arginine synthesis.

FEBS letters - 5 Jan 2009

Sancho-Vaello Enea, Fernández-Murga María L, Rubio Vicente

Abstract excerpt

N-acetyl-L-glutamate synthase (NAGS), the first enzyme of arginine biosynthesis in bacteria/plants and an essential urea cycle activator in animals, is, respectively, arginine-inhibited and activated. Arginine binds to the hexameric ring-forming amino acid kinase (AAK) domain of NAGS. We show tha...

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Identifiers

PMID: 19084009
DOI: 10.1016/j.febslet.2008.12.001

Genes

NAGS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19084009-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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