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Article

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.

Blood - 1 Nov 2004

Clark Jennifer J, Cools Jan, Curley David P, Yu Jin-Chen, Lokker Nathalie A, Giese Neill A, Gilliland D Gary

Abstract excerpt

FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop mutations in acute myeloid leukemia (AML). We tested the sensitivity of 8 activation loop mutations to the small molecule FLT3 inhibitor, MLN518. Each FLT3 activation loop mutant, including D835Y, D835A, D835E, D835H, D835N, D835V, D835del, and I836del, transformed Ba/F3 cells to...

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Source

Identifiers

PMID: 15256420
DOI: 10.1182/blood-2003-12-4446

Genes

FLT3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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