Article
High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type.
International journal of cancer - 20 May 2003
Van Limpt Vera A E, Chan Alvin J, Van Sluis Peter G, Caron Huib N, Van Noesel Carel J M, Versteeg Rogier
Abstract excerpt
The childhood tumour neuroblastoma originates from neural crest-derived progenitors of the sympathetic nervous system. By Serial Analysis of Gene Expression (SAGE), we previously identified the Drosophila Delta homologue Dlk1 as one of the genes most highly expressed in the neuroblastoma cell line SK-N-FI. The Delta-Notch pathway controls many differentiation steps in Drosophila and man. We analysed expression of...
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