Article
Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma.
Cancer letters - 18 Oct 2005
Bourdeaut Franck, Trochet Delphine, Janoueix-Lerosey Isabelle, Ribeiro Agnès, Deville Anne, Coz Carole, Michiels Jean-François, Lyonnet Stanislas, Amiel Jeanne, Delattre Olivier
Abstract excerpt
Hereditary predisposition to neuroblastoma accounts for less than 5% of neuroblastomas and is probably heterogeneous. Recently, a predisposition gene has been mapped to 16p12-p13, but has not yet been identified. Occurrence of neuroblastoma in association with congenital central hypoventilation and Hirschsprung's disease suggests that genes, involved in the development of neural-crest-derived cells, may be...
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