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Article

Design of novel conformational and genotype-specific antigens for improving sensitivity of immunoassays for hepatitis C virus-specific antibodies.

Journal of clinical microbiology - 1 Aug 2005

Lin Sansan, Arcangel Phillip, Medina-Selby Angelica, Coit Doris, Ng Philip, Nguyen Steve, McCoin Colin, Gyenes Alex, Hu Celine, Tandeske Laura, Phelps Bruce, Chien David

Abstract excerpt

The current commercially licensed enzyme-linked immunosorbent assays (ELISAs) for hepatitis C virus (HCV) mainly use recombinant proteins containing linear epitopes. There is evidence, however, that conformational epitopes of HCV are more immunoreactive. Thus, we have designed an HCV antibody assay that employs a conformational protein, NS3NS4a PI (with functional protease and helicase activities), and a linear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16081931
DOI: 10.1128/JCM.43.8.3917-3924.2005
PMCID: PMC1234008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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