Article
Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Annals of neurology - 1 Mar 2005
Hernandez Dena G, Paisán-Ruíz Coro, McInerney-Leo Aideen, Jain Shushant, Meyer-Lindenberg Andreas, Evans E Whitney, Berman Karen F, Johnson Janel, Auburger Georg, Schäffer Alejandro A, Lopez Grisel J, Nussbaum Robert L, Singleton Andrew B
Abstract excerpt
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patient...
Topics
- Aged
- Amino Acid Sequence
- Animals
- DNA Mutational Analysis
- Dihydroxyphenylalanine
- Family Health
- Female
- Genetic Predisposition to Disease
- Genotype
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male