Article
Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Annals of neurology - 1 Mar 2005
Hernandez Dena G, Paisán-Ruíz Coro, McInerney-Leo Aideen, Jain Shushant, Meyer-Lindenberg Andreas, Evans E Whitney, Berman Karen F, Johnson Janel, Auburger Georg, Schäffer Alejandro A, Lopez Grisel J, Nussbaum Robert L, Singleton Andrew B
Abstract excerpt
We have recently identified mutations in a gene leucine-rich repeat kinase-2 (LRRK2), which cause autosomal dominant Parkinson's disease. Here, we describe two families with autosomal dominant Parkinson's disease caused by a LRRK2 G2019S mutation. We present here a clinical description of patients, including 6-(18)F-fluoro-L-dopa positron emission tomography and discuss the potential implications of this...
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