Article
Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
Parkinsonism & related disorders - 1 May 2009
Hasegawa Kazuko, Stoessl A Jon, Yokoyama Teruo, Kowa Hisayuki, Wszolek Zbigniew K, Yagishita Saburo
Abstract excerpt
BACKGROUND: Since the causative gene linked to PARK8 parkinsonism was identified as LRRK2, LRRK2 gene mutations have been found to occur in about 4% of patients with hereditary Parkinson disease (PD); this percentage is even higher in certain populations. Moreover, no clear clinical differences between PARK8-linked parkinsonism and sporadic PD have been identified. Neuropathologic findings have been diverse in...
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