Method for indirectly estimating gene-environment effect modification and power given only genotype frequency and odds ratio of environmental exposure.

Abstract excerpt

Both genes and environment are important determinants of disease. In this paper we model gene-environment effect modification on the odds ratio scale OR(GEID) and show how to indirectly estimate the effect and 95% confidence intervals (CI) for the simple case of no main genetic and environmental effects [i.e., OR(GE/D) = OR(GE/D) = 1]. A statistic is presented to test the null hypothesis OR(GE/D) = 1 and to...

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