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Unbiased contribution of the first two blastomeres to mouse blastocyst development

3 Aug 2005

Abstract excerpt

Several recent studies have proposed a model that the organization of the mouse blastocyst is determined by the pattern of early cleavages: the plane of first cleavage divides the two-cell embryo into embryonic (Em) and abembryonic (Ab) halves, while the timing of the second cleavages specifies which blastomere becomes the Em half. This model is still controversial because of conflicting observations in various...

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PMID: 16078274
DOI: 10.1002/mrd.20353

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