Article
Mutational analysis of 9 different tumour-associated genes in human malignant mesothelioma cell lines.
Oncology reports - 1 Sept 2005
Kumar Krishan, Rahman Qamar, Schipper Holger, Matschegewski Claudia, Schiffmann Dietmar, Papp Thilo
Abstract excerpt
Seven tumour suppressor genes (Chk1, Chk2, Apaf1, Rb1, p53, p16(INK4a) and p14(ARF)) and two oncogenes (N-ras and BRAF) were screened in nine human malignant melanoma (HMM) cell lines for point mutations or small deletions/insertions by DGGE, TGGE and SCCP analysis. For the first time in human mesothelioma, Chk1 gene mutations were detected in two of the nine investigated HMM cell lines. P53 gene mutations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.