Article
Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis.
Methods (San Diego, Calif.) - 1 Jul 2005
Youngman Elaine M, Green Rachel
Abstract excerpt
As it has become increasingly clear that the RNA components of the ribosome are central to its function, the in vitro analysis of mutations in the ribosomal RNAs has become an important tool for understanding the molecular details of ribosome function. However, the frequent dominant lethal phenotypes of mutations at interesting rRNA residues has long presented a hurdle to this analysis, as their lethality has...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.