NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene.

doi:10.2337/diab.41.4.521

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Article

NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene.

Diabetes - 1 Apr 1992

Cocozza S, Porcellini A, Riccardi G, Monticelli A, Condorelli G, Ferrara A, Pianese L, Miele C, Capaldo B, Beguinot F

Abstract excerpt

A population of 103 patients with non-insulin-dependent diabetes mellitus (NIDDM) was screened for mutations in the tyrosine kinase domain of the insulin receptor gene. Patient genomic DNAs corresponding to exons 17-21 of the insulin receptor gene have been amplified by polymerase chain reaction and analyzed by denaturing gradient gel electrophoresis (DGGE). One patient was identified with an altered pattern of...

Topics

Alleles
Amino Acid Sequence
Base Sequence
DNA
Diabetes Mellitus, Type 2
Electrophoresis, Polyacrylamide Gel
Erythrocytes
Exons
Female
Genes
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Insulin Resistance

Male

Middle Aged

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 1607076
DOI: 10.2337/diab.41.4.521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1607076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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