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Article

Major gene effect for insulin levels in familial NIDDM pedigrees.

Diabetes - 1 Apr 1992

Schumacher M C, Hasstedt S J, Hunt S C, Williams R R, Elbein S C

Abstract excerpt

Insulin resistance and hyperinsulinemia are familial traits that may precede and predict the onset of non-insulin-dependent diabetes mellitus (NIDDM). In some populations, the distribution of fasting insulin levels and measures of in vivo insulin action suggest the effects of a single major gene. We previously noted hyperinsulinemia among unaffected members of 16 large white pedigrees ascertained through two or...

Topics

Adult
Alleles
Diabetes Mellitus, Type 2
Female
Genetic Variation
Glucose Tolerance Test
Homozygote
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

World Health Organization

Source

Identifiers

PMID: 1607068
DOI: 10.2337/diab.41.4.416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1607068-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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