Article
3D-extravasation model -- selection of highly motile and metastatic cancer cells.
Seminars in cancer biology - 1 Oct 2005
Brandt Burkhard, Heyder Christoph, Gloria-Maercker Eva, Hatzmann Wolfgang, Rötger Antje, Kemming Dirk, Zänker Kurt S, Entschladen Frank, Dittmar Thomas
Abstract excerpt
Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identification of genes, which are the key players at switchboards of the intracellular signaling...
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