Article
A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis.
The Journal of biological chemistry - 30 Sept 2005
Stephenson Sarah E M, Dubach Daphne, Lim Chris M, Mercer Julian F B, La Fontaine Sharon
Abstract excerpt
The homeostatic regulation of essential elements such as copper requires many proteins whose activities are often mediated and tightly coordinated through protein-protein interactions. This regulation ensures that cells receive enough copper without intracellular concentrations reaching toxic levels. To date, only a small number of proteins implicated in copper homeostasis have been identified, and little is...
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