Article
A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis.
The Journal of biological chemistry - 30 Sept 2005
Stephenson Sarah E M, Dubach Daphne, Lim Chris M, Mercer Julian F B, La Fontaine Sharon
Abstract excerpt
The homeostatic regulation of essential elements such as copper requires many proteins whose activities are often mediated and tightly coordinated through protein-protein interactions. This regulation ensures that cells receive enough copper without intracellular concentrations reaching toxic levels. To date, only a small number of proteins implicated in copper homeostasis have been identified, and little is...
Topics
- Adenosine Triphosphatases
- Alternative Splicing
- Amino Acid Motifs
- Amino Acid Sequence
- Binding Sites
- Carrier Proteins
- Cation Transport Proteins
- Cell Line, Transformed
- Copper
- Copper-Transporting ATPases
- Fibroblasts
- Gene Library
- Genetic Variation