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Article

Human copper-transporting ATPase ATP7B (the Wilson's disease protein): biochemical properties and regulation.

Journal of bioenergetics and biomembranes - 1 Oct 2002

Lutsenko Svetlana, Efremov Roman G, Tsivkovskii Ruslan, Walker Joel M

Abstract excerpt

Wilson's disease protein (WNDP) is a product of a gene ATP7B that is mutated in patients with Wilson's disease, a severe genetic disorder with hepatic and neurological manifestations caused by accumulation of copper in the liver and brain. In a cell, WNDP transports copper across various cell membranes using energy of ATP-hydrolysis. Copper regulates WNDP at several levels, modulating its catalytic activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12539962
DOI: 10.1023/a:1021297919034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human copper-transporting ATPase ATP7B (the Wilson's disease protein): biochemical properties and regulation.PMID 12539962Read ↗

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Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B.Semantic proximity Read ↗

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