Article
Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.
Annals of the New York Academy of Sciences - 1 Apr 2003
Goellner Geoffrey M, DeMarco Steven J, Strehler Emanuel E
Abstract excerpt
Plasma membrane Ca(2+) ATPases (PMCAs) maintain intracellular Ca(2+) homeostasis and participate in the local regulation of Ca(2+) signaling. Spatially separate demands for Ca(2+) regulation require proper membrane targeting of PMCAs, but the mechanism of PMCA targeting is unknown. Using the PMCA2b carboxyl-terminal tail as yeast two-hybrid bait, we isolated a novel PDZ domain-containing protein from a human...
Topics
- Adaptor Proteins, Signal Transducing
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Binding Sites
- Brain
- Calcium-Transporting ATPases
- Carrier Proteins
- Cation Transport Proteins
- Cell Line