Exclusion of alternative exon 33 of Ca V 1.2 calcium channels in heart is proarrhythmogenic

Abstract excerpt

Significance To directly address in vivo significance of the altered Ca V 1.2 channel property arising from alternative splicing, we generated Ca V 1.2 exon 33-specific knockout (exon 33 −/− ) mice. Here, we showed that the exclusion of alternative exon 33 altered Ca V 1.2 biophysical property, leading to greater I Ca density. This increase in current density induced prolongation of ventricular cardiomyocyte...

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