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Article

Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA.

Neurobiology of disease - 1 Dec 2005

Wang Jiou, Xu Guilian, Slunt Hilda H, Gonzales Victoria, Coonfield Michael, Fromholt David, Copeland Neal G, Jenkins Nancy A, Borchelt David R

Abstract excerpt

Familial amyotrophic lateral sclerosis (FALS) has been modeled in transgenic mice by introducing mutated versions of human genomic DNA encompassing the entire gene for Cu,Zn superoxide dismutase (SOD1). In this setting, the transgene is expressed throughout the body and results in mice that faithfully recapitulate many pathological and behavioral aspects of FALS. By contrast, transgenic mice made by introducing...

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PMID: 16046140
DOI: 10.1016/j.nbd.2005.06.005

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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