Article
A system for inducible gene expression in retinal ganglion cells.
Investigative ophthalmology & visual science - 1 Aug 2005
Kerrison John B, Duh Elia J, Yu Yilin, Otteson Deborah C, Zack Donald J
Abstract excerpt
PURPOSE: To develop a system for inducible gene expression in retinal ganglion cells, Thy1 and ckit promoters were used to direct expression of a second-generation reverse tetracycline transactivator (rtTA2S-M2). METHODS: Transgenic mice were generated that harbor rtTA2S-M2 under the control of either the Thy1 or ckit promoter. These animals were crossed with mice transgenic for the LacZ gene downstream of a...
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