Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas.

doi:10.1007/s00432-005-0016-1

Article

Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas.

Journal of cancer research and clinical oncology - 1 Oct 2005

Gwak G-Y, Yoon J-H, Shin C M, Ahn Y J, Chung J K, Kim Y A, Kim T-Y, Lee H-S

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) signalings have recently been implicated in the genesis and progression of cholangiocarcinomas. Thus, the EGFR kinase inhibitor appears to be promising in the treatment of this cancer. The response-predicting mutations in the tyrosine kinase domain of EGFR gene have recently been detected in non-small cell lung cancers. This study was, therefore, to investigate if...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas.

Abstract excerpt

Topics

Related research