Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2005

Burts Monica L, Williams Wade A, DeBord Kristin, Missiakas Dominique M

Abstract excerpt

Mycobacterium tuberculosis secretes ESAT-6, a virulence factor that triggers cell-mediated immune responses and IFN-gamma production during tuberculosis. ESAT-6 is transported across the bacterial envelope by a specialized secretion system with a FSD (FtsK-SpoIIIE domain) membrane protein. Although the presence of ESAT-6-like genes has been identified in the genomes of other microbes, the possibility that they...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abscess
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Bacterial

Share to Bacterial Proteins

Share to Mice, Inbred BALB C

Share to Staphylococcal Infections

Share to Staphylococcus aureus

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 15657139
DOI: 10.1073/pnas.0405620102
PMCID: PMC545836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.PMID 15657139Read ↗

EsaC substrate for the ESAT‐6 secretion pathway and its role in persistent infections of <i>Staphylococcus aureus</i>Semantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulenceSemantic proximity Read ↗

Mutually dependent secretion of proteins required for mycobacterial virulenceSemantic proximity Read ↗

Isolation of a Membrane Protein Complex for Type VII Secretion in Staphylococcus aureus.Semantic proximity Read ↗

ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosisSemantic proximity Read ↗

EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus.Semantic proximity Read ↗

ESX‐1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteriaSemantic proximity Read ↗

A specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies WhiB6 as a novel ESX-1 component.Semantic proximity Read ↗

Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1Semantic proximity Read ↗

EssD, a Nuclease Effector of the Staphylococcus aureus ESS PathwaySemantic proximity Read ↗

The regulatory functions of ESX-1 substrates, EspE and EspF, are separable from secretionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.