Article
Polymorphisms of the dopamine receptor gene DRD2 and colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2005
Gemignani Federica, Landi Stefano, Moreno Victor, Gioia-Patricola Lydie, Chabrier Amélie, Guino Elisabet, Navarro Matilde, Cambray Maria, Capellà Gabriel, Canzian Federico
Abstract excerpt
Sporadic colorectal cancer is considered a multifactorial disease in which multiple exposures interact with the individual genetic background resulting in risk modulation. Recent experimental data suggest a role of dopamine and dopamine receptors in the control of proliferation of the cells of colon and gastrointestinal tract. To investigate whether polymorphisms within dopamine receptors genes could have a role...
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