Article
Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment.
Digestive diseases and sciences - 1 Nov 2006
Magro F, Cunha E, Araujo F, Meireles E, Pereira P, Dinis-Ribeiro M, Veloso F Tavarela, Medeiros R, Soares-da-Silva P
Abstract excerpt
Dopamine and its receptors may be involved in inflammatory reaction. The availability of this molecule depends on its receptors. The DRD2 gene, which codifies for the D2 dopamine receptor, has several polymorphisms. In this study, the DRD2 TaqIA polymorphism, which confers a decreased receptor density, was evaluated in 313 individuals including 220 inflammatory bowel disease patients (143 patients with Crohn's...
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