Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1.

doi:10.1128/JVI.66.7.4445-4451.1992

Article

Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1.

Journal of virology - 1 Jul 1992

Fujita K, Silver J, Peden K

Abstract excerpt

Virus derived from an infectious molecular clone of the ELI strain of human immunodeficiency virus type 1 (HIV-1) replicates well in peripheral blood mononuclear cells and in some CD4-positive cell lines but exhibits a delayed time course of infection in CEM and H9 cells and fails to infect SupT1...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
DNA, Viral
HIV Envelope Protein gp120
HIV Envelope Protein gp41
HIV-1
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sequence Homology, Nucleic Acid
Serial Passage
T-Lymphocytes
Virus Replication

Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1.

Abstract excerpt

Topics

Discuss the evidence