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Article

Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein

15 Jun 2005

Abstract excerpt

Equine influenza is a common disease of the horse, causing significant morbidity worldwide. Here we describe the establishment of a plasmid-based reverse genetics system for equine influenza virus. Utilizing this system, we generated three mutant viruses encoding carboxy-terminally truncated NS1 proteins. We have previously shown that a recombinant human influenza virus lacking the NS1 gene (delNS1) could only...

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PMID: 15956587
DOI: 10.1128/jvi.79.13.8431-8439.2005

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