Article
Complementation of a replication-defective mutant of equine herpesvirus type 1 by a cell line expressing the immediate-early protein.
Virology - 15 Aug 1998
Garko-Buczynski K A, Smith R H, Kim S K, O'Callaghan D J
Abstract excerpt
Equine herpesvirus type 1 (EHV-1) possesses a sole, diploid immediate-early (IE) gene that encodes a major regulatory protein of 1487 amino acids capable of modulating expression of both early and late EHV-1 promoters and capable of trans-repressing its own promoter. In this study, a rabbit kidney cell line (IE13.1) that constitutively expresses the EHV-1 IE protein was generated by cotransfection of rabbit...
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