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Article

Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.

Molecular and cellular biology - 1 Aug 2005

Bader Bernhard L, Smyth Neil, Nedbal Sabine, Miosge Nicolai, Baranowsky Anke, Mokkapati Sharada, Murshed Monzur, Nischt Roswitha

Abstract excerpt

Nidogen 1 and 2 are basement membrane glycoproteins, and previous biochemical and functional studies indicate that they may play a crucial role in basement membrane assembly. While they show a divergent expression pattern in certain adult tissues, both have a similar distribution during development. Gene knockout studies in mice demonstrated that the loss of either isoform has no effect on basement membrane...

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Identifiers

PMID: 16024816
DOI: 10.1128/MCB.25.15.6846-6856.2005
PMCID: PMC1190363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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