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Article

[Leber's optic neuropathy: new diagnostic prospects].

Journal francais d'ophtalmologie - 1 Jan 1992

Pagot V, Malecaze F, Rötig A, Simorre V, Maillard P, Mathis A, Munnich A

Abstract excerpt

The diagnosis of Leber's hereditary optic neuropathy, essentially based on a family history of a similar illness, becomes difficult in sporadic cases. In this disease, mitochondrial DNA mutations have been recently discovered and detected by digestion with restriction enzyme after amplification by the Polymerase Chain Reaction. We present two patients in whom these molecular biological techniques confirmed the...

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Share to DNA, Mitochondrial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Optic Atrophies, Hereditary

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Source

Identifiers

PMID: 1602101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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[Leber's optic neuropathy: new diagnostic prospects].PMID 1602101Read ↗

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[New mitochondrial DNA mutation in Leber's hereditary optic neuropathy: A case report].Semantic proximity Read ↗

Leber's hereditary optic neuropathy. New genetic considerations.Semantic proximity Read ↗

[Positive diagnosis of Leber's hereditary optic neuropathy using molecular genetics].Semantic proximity Read ↗

[Genetic basis of Leber's hereditary optic neuroretinopathy].Semantic proximity Read ↗

[Clinical examination of Leber hereditary optic neuropathy in patients with the same gene mutation].Semantic proximity Read ↗

[Leber hereditary optic neuropathy: clinical picture and initial workup data].Semantic proximity Read ↗

[Leber hereditary optic neuropathy: Usefulness of next generation sequencing to study mitochondrial mutations on apparent homoplasmy].Semantic proximity Read ↗

Leber hereditary optic neuropathy: clinical and molecular genetic findings.Semantic proximity Read ↗

[Leber's hereditary optic neuropathy: DNA-diagnosis and clinico-genetic comparisons in 12 families].Semantic proximity Read ↗

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