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Article

[Leber's hereditary optic neuropathy: DNA-diagnosis and clinico-genetic comparisons in 12 families].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2003

Zakharova E Iu, Rudenskaia G E, Karlova I Z, Adarcheva L S, Mikhaĭlova E N

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a worldwide spread neuro-ophthalmologic disease characterized by immediate pronounced visual reduction with a picture of retrobulbar neuritis, following by optic atrophy. The disease is caused by mitochondrial DNA mutations. Molecular genetic structure of 12 families, including 26 LHON patients, 13 of them being examined, is presented. All of the main primary...

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PMID: 12938654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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