[Molecular genetic analysis for Leber's hereditary optic neuropathy (LHON)].

Article

[Molecular genetic analysis for Leber's hereditary optic neuropathy (LHON)].

Nihon rinsho. Japanese journal of clinical medicine - 1 Sept 1993

Tanno Y, Yoneda M, Tanaka K, Tsuji S

Abstract excerpt

Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease characterized of acute visual loss predominantly affecting young men. So far twelve mutations in the mitochondrial DNA have been associated in this disease. We reviewed these mutations, and showed methods to detect these...

Topics

Base Sequence
DNA, Mitochondrial
Female
Humans
Male
Molecular Sequence Data
Mutation
Optic Atrophies, Hereditary
Pedigree
Polymerase Chain Reaction

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