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Article

Phenotype-genotype correlations in mouse models of amelogenesis imperfecta caused by Amelx and Enam mutations.

Cells, tissues, organs - 1 Jan 2012

Coxon Thomas Liam, Brook Alan Henry, Barron Martin John, Smith Richard Nigel

Abstract excerpt

Mutations in human and in mouse orthologous genes Amelx and Enam result in a diverse range of enamel defects. In this study we aimed to investigate the phenotype-genotype correlation between the mutants and the wild-type controls in mouse models of amelogenesis imperfecta using novel measurement approaches. Ten hemi-mandibles and incisors were dissected from each group of Amelx(WT), Amelx(X/Y64H), Amelx(Y/Y64H),...

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Identifiers

PMID: 22759786
DOI: 10.1159/000336440
PMCID: PMC3718574

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Source receipt: pubmed, retrieved 7 Sept 2026.

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