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Article

C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells.

Atherosclerosis - 1 Mar 2006

Kawanami Daiji, Maemura Koji, Takeda Norihiko, Harada Tomohiro, Nojiri Takefumi, Saito Tetsuya, Manabe Ichiro, Imai Yasushi, Nagai Ryozo

Abstract excerpt

Recent studies have shown that C-reactive protein (CRP) is not just a predictor of cardiovascular events but also acts directly as a proinflammatory stimulus in vascular cells. In this report, we studied the molecular mechanisms underlying vascular cellular adhesion molecule-1 (VCAM-1) induction by CRP. CRP-induced VCAM-1 mRNA expression and this induction was inhibited by protein kinase C (PKC) inhibitors, p38...

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Identifiers

PMID: 16002075
DOI: 10.1016/j.atherosclerosis.2005.01.057

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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