Article
Molecular and immunohistochemical investigation of protein kinase a regulatory subunit type 1A (PRKAR1A) in odontogenic myxomas.
Genes, chromosomes & cancer - 1 Oct 2005
Perdigão Paola F, Stergiopoulos Sotirios G, De Marco Luiz, Matyakhina Ludmila, Boikos Sosipatros A, Gomez R S, Pimenta F J G S, Stratakis Constantine A
Abstract excerpt
Odontogenic myxomas are rare benign neoplasms affecting the jaw. Myxomas of bones and other sites occur as part of Carney complex (CNC), a multiple neoplasia syndrome caused by mutations in the PRKAR1A gene, which codes for the regulatory subunit of protein kinase A (PKA). In the present study, 17 odontogenic myxomas from patients without CNC were screened for PRKAR1A mutations and PRKAR1A protein expression by...
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