Article
Defects of the Carney complex gene (PRKAR1A) in odontogenic tumors.
Endocrine-related cancer - 1 Jun 2015
Sousa Sílvia F, Gomez Ricardo S, Diniz Marina G, Bernardes Vanessa F, Soares Flávia F C, Brito João Artur R, Liu Sophie, Pontes Hélder Antônio R, Stratakis Constantine A, Gomes Carolina C
Abstract excerpt
The surgical treatment of some odontogenic tumors often leads to tooth and maxillary bone loss as well as to facial deformity. Therefore, the identification of genes involved in the pathogenesis of odontogenic tumors may result in alternative molecular therapies. The PRKAR1A gene displays a loss of protein expression as well as somatic mutations in odontogenic myxomas, an odontogenic ectomesenchymal neoplasm. We...
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