Article
Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention.
In vivo (Athens, Greece) - 1 Jan 2000
Berrigan David, Lavigne Jackie A, Perkins Susan N, Nagy Tim R, Barrett J Carl, Hursting Stephen D
Abstract excerpt
BACKGROUND: Calorie restriction (CR) inhibits carcinogenesis and delays aging. Some anti-carcinogenic effects of CR are mediated by decreased circulating insulin-like growth factor-1 (IGF-1); however, IGF-1 also plays an important role in regulating growth and bone density. MATERIALS AND METHODS: We quantified tradeoffs involving the CR/IGF-1 axis in C57BL/6 mice by examining body composition and bone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.