Article
Association study of CREB1 and childhood-onset mood disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Aug 2005
Burcescu I, Wigg K, King N, Vetró A, Kiss E, Katay L, Kennedy J L, Kovacs M, Barr C L
Abstract excerpt
Several lines of evidence suggest that the cellular pathways involved in synaptic plasticity contribute to the risk of depression. These findings include the evidence that chronic antidepressant treatment upregulates the cAMP signal transduction cascade resulting in increased expression and function of the cAMP responsive element binding protein (CREB), a transcription factor that increases the expression of key...
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