Synthesis of DNA conjugate by mechanochemical solid-state polymerization and its affinity separation of oligonucleotides having single-base difference by capillary electrophoresis.

Abstract excerpt

In this communication, we discuss the characterization of DNA conjugate synthesized by mechanochemical polymerization, Con-M, on the separation of model oligo-DNA and its single nucleotide polymorphisms (SNPs) by affinity capillary electrophoresis, compared with that prepared by radical-initiated solution polymerization, Con-RL. The average molecular weight of Con-M was similar to that of Con-RL, although the...

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