Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thermodynamics-based rational design of DNA block copolymers for quantitative detection of single-nucleotide polymorphisms by affinity capillary electrophoresis.

Analytical chemistry - 18 Nov 2014

Kimura Ayumi, Kanayama Naoki, Ogawa Atsushi, Shibata Hideaki, Nakashita Hideo, Takarada Tohru, Maeda Mizuo

Abstract excerpt

Diblock copolymers composed of allele-specific oligodeoxyribonucleotide (ODN) and poly(ethylene glycol) (PEG) are used as an affinity probe of free-solution capillary electrophoresis to quantitatively detect single-base substitutions in genetic samples. During electrophoresis, the probe binds strongly to a wild-type single-stranded DNA analyte (WT) through hybridization, while it binds weakly to its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Electrophoresis, Capillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligodeoxyribonucleotides

Share to Polyethylene Glycols

Share to Polymorphism, Single Nucleotide

Share to Thermodynamics

Source

Identifiers

PMID: 25358129
DOI: 10.1021/ac503522f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thermodynamics-based rational design of DNA block copolymers for quantitative detection of single-nucleotide polymorphisms by affinity capillary electrophoresis.PMID 25358129Read ↗

Quantitative SNP genotyping by affinity capillary electrophoresis using PEG-oligodeoxyribonucleotide block copolymers with electroosmotic flow.Semantic proximity Read ↗

Evaluation of single-base substitution rate in DNA by affinity capillary electrophoresis.Semantic proximity Read ↗

Quantitative single-nucleotide polymorphism analysis in secondary-structured DNA by affinity capillary electrophoresis using a polyethylene glycol-peptide nucleic acid block copolymer.Semantic proximity Read ↗

RAFT-generated polyacrylamide-DNA block copolymers for single-nucleotide polymorphism genotyping by affinity capillary electrophoresis.Semantic proximity Read ↗

Dumbbell-shaped DNA analytes amplified by polymerase chain reaction for robust single-nucleotide polymorphism genotyping by affinity capillary electrophoresis.Semantic proximity Read ↗

Affinity capillary electrophoresis of DNA for detection of single-nucleotide polymorphisms and point mutations. Comprehensive study for optimization of the weak affinity.Semantic proximity Read ↗

Synthesis of DNA conjugate by mechanochemical solid-state polymerization and its affinity separation of oligonucleotides having single-base difference by capillary electrophoresis.Semantic proximity Read ↗

Cationic comb-type copolymers for DNA analysis.Semantic proximity Read ↗

Capillary electrophoretic discrimination of single nucleotide polymorphisms using an oligodeoxyribonucleotidepolyacrylamide conjugate as a pseudo-immobilized affinity ligand: optimum ligand length predicted by the melting temperature values.Semantic proximity Read ↗

Multiplexed p53 mutation detection by free-solution conjugate microchannel electrophoresis with polyamide drag-tags.Semantic proximity Read ↗

A gel-based solid-phase amplification and its application for SNP typing and sequencing on-chip.Semantic proximity Read ↗

Single-Nucleotide-Specific Lipidic Nanoflares for Precise and Visible Detection of KRAS Mutations via Toehold-Initiated Self-Priming DNA Polymerization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.