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Article

Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2005

Laakso Mervi, Loman Niklas, Borg Ake, Isola Jorma

Abstract excerpt

Breast ducts contain two types of epithelial cells, inner luminal cells and outer basal/myoepithelial cells. These cells can be distinguished by their immunophenotype. Cytokeratins (CKs) 8 and 18 are expressed in the luminal layer, whereas CK5/14 and the transcription factor p63 characterize the basal epithelial layer. We studied a population-based cohort of 288 sporadic ductal invasive cancers and found 9%...

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Source

Identifiers

PMID: 15990899
DOI: 10.1038/modpathol.3800456

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors.PMID 15990899Read ↗

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CK8/18 expression, the basal phenotype, and family history in identifying BRCA1-associated breast cancer in the Ontario site of the breast cancer family registry.Semantic proximity Read ↗

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype.Semantic proximity Read ↗

Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile.Semantic proximity Read ↗

Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer.Semantic proximity Read ↗

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breastSemantic proximity Read ↗

Immunohistochemical Staining Characteristics of Well Differentiated Invasive Ductal Carcinoma Using the ADH5 Cocktail (CK5/14, P63, and CK7/18): a Potential Interpretative PitfallSemantic proximity Read ↗

Ck5-positive cells are precursor cells of glandular and myoepithelial cell lineages in the human breast epithelium. A new cell concept as a basis for a better understanding of proliferative breast disease?Semantic proximity Read ↗

Polarity gene alterations in pure invasive micropapillary carcinomas of the breastSemantic proximity Read ↗

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