Article
Cytokeratin 5/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2005
Laakso Mervi, Loman Niklas, Borg Ake, Isola Jorma
Abstract excerpt
Breast ducts contain two types of epithelial cells, inner luminal cells and outer basal/myoepithelial cells. These cells can be distinguished by their immunophenotype. Cytokeratins (CKs) 8 and 18 are expressed in the luminal layer, whereas CK5/14 and the transcription factor p63 characterize the...
Topics
- BRCA1 Protein
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Cohort Studies
- DNA-Binding Proteins
- Female
- Genes, Tumor Suppressor
- Genes, erbB-2
- Humans
- Immunohistochemistry
- Keratins
- Middle Aged
- Neoplasm Invasiveness
- Phenotype
- Phosphoproteins
- Receptor, ErbB-2
- Trans-Activators
- Transcription Factors