[Construction of superagonist mutein of human CNTF and its expression in Pichia pastoris].

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Article

[Construction of superagonist mutein of human CNTF and its expression in Pichia pastoris].

Wei sheng wu xue bao = Acta microbiologica Sinica - 1 Jun 2005

Zhao Hong-liang, Xue Chong, Xiong Xiang-hua, Zhang Wei, Liu Zhi-min

Abstract excerpt

Human ciliary neurotrophic factor (hCNTF) and its derivatives are promising therapeutics for obesity associated with diabetes. To reduce its side effects and increase its efficacy, superagonist mutein of human CNTF was constructed by the introduction of S165D/Q166H mutation into AX15(R13K), which is a mutein of naturally occurring hCNTF, with improved biological activity, stability, solubility and KEX2...

Topics

Animals
Anti-Obesity Agents
Cell Line
Cell Survival
Ciliary Neurotrophic Factor
Humans
Mice
Mice, Inbred Strains
Mutation
Pichia

Source

Open in PubMed

Identifiers

PMID: 15989233

Genes

CNTF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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