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Article

Loss of histochemical identity in mast cells lacking carboxypeptidase A.

Molecular and cellular biology - 1 Jul 2005

Feyerabend Thorsten B, Hausser Heinz, Tietz Annette, Blum Carmen, Hellman Lars, Straus Anita H, Takahashi Hélio K, Morgan Ellen S, Dvorak Ann M, Fehling Hans Jörg, Rodewald Hans-Reimer

Abstract excerpt

Mast cell carboxypeptidase A (Mc-cpa) is a highly conserved secretory granule protease. The onset of expression in mast cell progenitors and lineage specificity suggest an important role for Mc-cpa in mast cells. To address the function of Mc-cpa, we generated Mc-cpa-null mice. Mc-cpa-/- mast cells lacked carboxypeptidase activity, revealing that Mc-cpa is a nonredundant enzyme. While Mc-cpa-/- peritoneal mast...

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Identifiers

PMID: 15988029
DOI: 10.1128/MCB.25.14.6199-6210.2005
PMCID: PMC1168831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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