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Article

Carboxypeptidase A3-A Key Component of the Protease Phenotype of Mast Cells.

Cells - 6 Feb 2022

Atiakshin Dmitri, Kostin Andrey, Trotsenko Ivan, Samoilova Vera, Buchwalow Igor, Tiemann Markus

Abstract excerpt

Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression. This protease is one of the preformed components of the secretome. During maturation of granules, CPA3 becomes an active enzyme with a characteristic localization determining the features of the cytological and ultrastructural phenotype of MC. CPA3 takes part in the regulation of a specific tissue microenvironment,...

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PMID: 35159379
DOI: 10.3390/cells11030570
PMCID: PMC8834431

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