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Article

Sequence variation in the tRNA genes of human mitochondrial DNA.

Journal of molecular evolution - 1 May 2005

Vilmi Tiina, Moilanen Jukka S, Finnilä Saara, Majamaa Kari

Abstract excerpt

Recent analyses have shown that nonsynonymous variation in human mitochondrial DNA (mtDNA) contains nonneutral variants, suggesting the presence of mildly deleterious mutations. Many of the disease-causing mutations in mtDNA occur in the genes encoding the tRNAs. Nucleotide sequence variation in these genes has not been studied in human populations, nor have the structural consequences of nucleotide substitutions...

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PMID: 15983868
DOI: 10.1007/s00239-003-0202-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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