Article
Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.
Nucleic acids research - 25 May 1992
Moshier J A, Osborne D L, Skunca M, Dosescu J, Gilbert J D, Fitzgerald M C, Polidori G, Wagner R L, Friezner Degen S J, Luk G D
Abstract excerpt
Overexpression of the ornithine decarboxylase (ODC) gene may be important to the development and maintenance of colonic neoplasms, as well as tumors in general. In this study, we examined the promoter elements governing constitutive expression of the human ODC gene in HCT 116 human colon carcinom...
Topics
- Base Sequence
- Binding Sites
- Blotting, Northern
- Cell Line, Transformed
- Colonic Neoplasms
- DNA-Binding Proteins
- Deoxyribonuclease I
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Sequence Data
- Mutation
- Ornithine Decarboxylase
- Plasmids
- Promoter Regions, Genetic